What are Xanthones? Xanthones are biologically active plant phenols found in a few select tropical plants. Current research on xanthones suggests they are beneficial in helping with many conditions including: allergies, infections (microbial, fungus, viral), cholesterol levels, inflammation, skin disorders, gastro-intestinal disorders, and fatigue.
Xanthones have been found to support and enhance the body's immune system. Xanthones also exhibit strong antioxidant activity which is beneficial for neutralizing free radicals in the body.
Facts about xanthones:
· The most plentiful natural source of xanthones is in the mangosteen (Garcinia mangostana). The mangosteen has by far the most xanthones of any plant. The pericarp of the mangosteen fruit contains the vast majority of the xanthones.
· Xanthones are some of the most potent antioxidants known. It is thought to be more potent than both Vitamin C and Vitamin E. In fact, many doctors refer to xanthones as "Super Antioxidants."
· Xanthones are heat stable molecules. Unlike proteins, they won't denature or lose their structure when heated.
List of Xanthones in Mangosteen
Here is a list of all of the xanthones that have been named and found in the mangosteen. There are others that have not been named yet that I have not included in this list. Currently, there are 43 xanthones found in XangoTM Juice.
BR-xanthone A
BR-xanthone B
Calabaxanthone
Garcinone A
Garcinone B
Garcinone C
Garcinone D
Garcinone E
Gamma-Mangostin
Garcimangosone A
Garcimangosone B
Garcimangosone C
1-Isomangostin
3-Isomangostin
1-Isomangostin hydrate
3-Isomangostin hydrate
Gartanin
Demethylcalabaxanthone
Maclurin
Mangostenone
Mangostanin
Mangostanol
Mangostin
Mangostinone
Mangostinone A
Mangostinone B
a-Mangostin
b-Mangostin
g-Mangostin
Norathriol
Tovophyllin
Tovophyllin A
Tovophyllin B
Trapezifolixanthone
Medical Properties of Xanthones:
Research on Xanthones is ongoing. There are many results reported about health benefits from xanthones that has not been explained by science yet. This is likely due to the fact that only about 15% of known xanthones have been studied to any degree.
Some of the known benefits of xanthones based on recent research are:
· Anti-Fatigue - Helps boost energy.
· Anti-Inflammatory - Helps prevent and reduce inflammation
· Anti-Ageing
· Helps prevent cancer. According to a preliminary study, six xanthones have been found to be capable of killing cancer cells.
· Helps lower blood pressure
· Helps lower blood sugar. Many people with type II diabetes have reported that it helps them to regulate their blood sugar levels.
· Helps prevent infections; bacteria, microbes, viruses and fungi.
· Anti-diarrhoeal: In folk medicine, the pericarp of the mangosteen (most potent source of xanthones) has been used for centuries to effectively treat dysentery.
· Anti-Parkinson, Anti-Alzheimer. Helps prevent dementia.
· Anti-allergenic. Helps with allergies
· Eye Care: Helps prevents cataracts and glaucoma
· Helps protect the heart and cardiovascular system
· Anti-Obesity
A recent study has confirmed that gamma mangostin, a xanthones derivative found in the mangosteen, is a potent COX (Cyclooxgenase) 2 inhibitor. The COX 2 enzyme is a chemical in the body that causes inflammation. This enzyme is commonly found in people suffering from joint pain and arthritis. However, it is also being found with other diseases as well, that are not as obvious, such as Parkinson's, Alzheimer's, cancer, and diabetes. In three separate studies, a xanthones derivative of the mangosteen slowed down the body's production of the COX 2 enzyme.
Medical Uses of Xanthones
This information is based of the research of Dr. J. Frederic Templeman, M.D.
Here is a list of medical conditions that Dr. Templeman uses mangosteen and xanthones contained within the fruit as first line treatment in his medical practice:
· ERD (gastro-esophageal reflux disease)
· Hiatal hernia
· Diverticulitis
· Arthritis
· Sleep disorders
· Irritable bowel disease (diarrhoeal type)
· Fibromyalgia
· Neurodermatitis
· Fatigue
· Eczema
· Mild depression
· Muscle or joint pain without evidence of Arthritis
· Seborrhea
· Recurrent urinary tract infections in the elderly
Disclaimer: Information herein is not intended to be taken as medical advice. No therapeutic or medical claims are either implied or made. Do not alter any medical treatment or the use of medications without the permission of your medical care provider.
Here is a list of prescription medications that Dr. Templeman has replaced with mangosteen and xanthones:
· Nexium, Prevacid, Aciphex, and other proton pump inhibitors.
· Zantac, Pepcid, and other H2 blockers.
· Allegra, Zyrtec, Claritin, Clarinex, and other antihistamines.
· Singulair, Prednisone
· Lotrisone, Topicort, Cutivate, Diprolene, and other topical Cortico Steroids used for skin conditions (Eczema, Psoriasis, Seborrhea)
· Valium, Xanax, and other minor tranquilizers.
· Tegretol, Neurontin, and other anti-epileptic drugs used (off label) for chronic pain relief.
· Prozac, Zoloft, Paxil, Lexapro, and other antidepressants when used for Dysthymia and anxiety states.
· Vicodin, Percocet, Duragesic patch, Methadone, and other narcotics used for chronic pain control.
· Celebrex, Vioxx, Bextra, Naproxen, Arthrotec, Ibuprofin, and other anti-inflammatories used for Musculo-Skeletal pain and inflammation.
· Ultram, Talwin, and other non-Opiod pain preparations.
· Midrin, Fioricet, Imitrex, Amerge, Maxalt, Zomig, and other Seretonergil Migraine headache preparations.
· Lipitor, Zolor, Pravacol, and other Lipid-lowering agents.
· Valtrex, and other anti-herpetic agents.
· Aricept, Cognex, and other Alzheimer’s preparations.
· Anusol, and other Hemorrhoid preparations
Recommended Dosage by Dr. Templeman
Many of the current products which contain xanthones are in a liquid form. Therefore, the following recommendations are based on taking a liquid form of a whole fruit mangosteen puree (be sure it includes the pericarp). Pills and capsules are generally less effective and are therefore not recommended.
Please consult with your doctor before beginning any dietary regiment.
For people in good health, the recommended maintenance dose is 1-2 oz per day. If you are regularly in an unhealthy environment (i.e. smoke filled bars, cities with heavy smog, etc.) then taking more is recommended due to the antioxidant power of xanthones.
The general rule of thumb if illness or disease is already present is 1-3 ounces before every meal with 2 ounces being the most common.
Here are some specific recommendations from Dr. J Frederic Templeman M.D.
· Asthma - 1oz 3 times daily
· Allergies - 1oz before every meal during allergy season.
· Heart Attack and Stroke - 1-2 oz before meals for existing disease 1oz per day for prevention
· Fibromyalgia - 1-2 oz before every meal
· Diverticulitis - 1 oz per day - Preparation should be strained before drinking
· Chronic Obstructive Pulmonary Disease - 1oz three times a day when symptoms present 1oz per day for prevention
· Multiple Sclerosis - 1-2oz 2-3 times a day.
· Cancer - 2-3oz 2-3 times a day if cancer is present 1oz 1-3 times a day for prevention. (In some cases, people have drank up to 25oz per day)
· Type II Diabetes - 1 ounce a day three times daily until results are noticed. Then slowly reduce to 1oz daily.
31 Mangosteen studies - summarized
From Narace D. Seudeal, Ph.D:
As a PhD in Clinical Biochemistry, I refuse to accept products without the research to back them up. I mean real hard core scientific studies and not some wishy washy test that has no relevance to the human condition. The XanGo mangosteen xanthones research is extensive and studied by PhD's, MD's and others from around the world. But, don't take my word for it. Read the summaries of just a few XanGo mangosteen xanthones research articles below. You be the judge.
Xanthones Research from Around the World Demonstrate the Potent Antioxidant Power of the Mangosteen Fruit in XanGo!
I have reviewed these selections of mangosteen xanthones research articles for you and condensed the main conclusions in easy to read format without much technical jargon, yet keeping the integrity of the medical findings intact. Bear in mind this is just a sampling of xanthones research. Natives of Asia used the mangosteen fruit for hundreds of years to heal a variety of medical sicknesses and ailments. They had no clue of the nature of the active ingredients in their concoctions of this miraculous fruit. Now, with the extensive mangosteen xanthones research done worldwide, we now know why those poultices and potions were so effective in treating so many medical sicknesses and ailments and endured the test of centuries. Narace D. Seudeal, Ph.D.
1) Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004 Jan;90(1):161-6. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand. pypmk@mahidol.ac.th
These investigators found that an extract from the pericarp of the mangosteen fruit (major component in XanGo) inhibited the growth of breast cancer cells. They also showed that the extract had potent antioxidant and cancer cell death properties. They concluded that the extract from the pericarp of the mangosteen fruit has potential for chemoprevention.
2) Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumoto@giib.or.jp
These authors examined the effects of six xanthones extracted from the pericarps of the mangosteen fruit, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin (a xanthone) showed the most potent ability to cause the cancer cells death.
3) Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. sunit@swu.ac.th
Xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, mangosteen fruit, were tested for their antituberculosis potential. The investigators found alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis (TB).
4) Garcinone E, a xanthone derivative, has potent cytotoxic effect against the patocellular carcinoma cell lines. Planta Med. 2002 Nov;68(11):975-9. Ho CK, Huang YL, Chen CC. Department of Medical Research and Education, Veterans General Hospital, Taipei, ROC.
Treatment of hepatocellular carcinomas (liver cancer) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. The investigators extracted and purified 6 xanthone compounds from the rinds (peel) of the fruit of Garcinia mangostana, mangosteen fruit. The investigators tested this extract on 14 different human liver cancer cell lines. Several chemotherapeutic agents (drugs) were included in the study for comparison. The results showed that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect (kill cells) on all liver cancer cell lines as well as on the other gastric and lung cancer cell lines included in the screen. The investigators suggested that garcinone E may be potentially useful for the treatment of certain types of cancer.
5) Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002 Sep;25(9):1137-41. Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
The fruit hull of mangosteen, Garcinia mangostana L., mangosteen fruit, has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated. The present study was undertaken to examine the effects of mangosteen fruit extracts on histamine release and prostaglandin E2 synthesis. The investigators found the mangosteen fruit extract strongly inhibited histamine release and prostaglandin E2 synthesis. This has great importance in preventing allergies.
6) Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol. 2002 Jan 1;63(1):73-9. Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan.
The fruit hull of mangosteen fruit, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia. In the present study, the investigators studied the effect of gamma-mangostin, a xanthone contained in the mangosteen fruit, and showed it had a potent inhibitory activity of prostaglandin E2 (PGE2) release.
7) Immunopharmacological activity of polysaccharide from the pericarp of mangosteen garcinia: phagocytic intracellular killing activities. J Med Assoc Thai. 1997 Sep;80 Suppl 1:S149-54. Chanarat P, Chanarat N, Fujihara M, Nagumo T. Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand.
Polysaccharides from the pericarps of mangosteen, Garcinia mangostana Linn., mangosteen fruit, were extracted from the dried ground pericarps of the mangosteen fruit. The results showed that the number of S. enteritidis (bacteria) in cultured monocyte with extract of the pericarp of the mangosteen fruit was killed. This paper showed that polysaccharides in the extract can stimulate phagocytic cells to kill intracellular bacteria (S. enteritidis).
8) Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med. 1996 Oct;62(5):471-2. Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y.
The investigators studied an extract of the fruit hull of Mangosteen, Garcinia mangostana L., mangosteen fruit. On the basis of pharmacological data, they determined that alpha-mangostin and gamma-mangostin (xanthones in mangostana) are a histaminergic and a serotonergic receptor blocking agent, respectively. That is, they have the ability to prevent allergies and inflammation.
9) Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radic Res. 2000 Nov;33(5):643-59. Mahabusarakam W, Proudfoot J, Taylor W, Croft K. Chemistry Department, Prince of Songkla University, Hat Yai, Thailand.
Oxidative damage is thought to play a critical role in cardiovascular and other chronic diseases. This has led to considerable interest in the antioxidant activity of dietary compounds. The researchers have previously shown that the xanthone, mangostin (found in mangosteen fruit), can inhibit the oxidation of LDL, low density lipoprotein (bad cholesterol). Researchers studied more xanthone derived compounds and found enhanced antioxidant activities. Note: If the oxidation of LDL cholesterol can be prevented or inhibited, then the LDL-cholesterol cannot exert its "bad" effect and cause heart disease.
10) Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med. 1998 Mar;64(2):97-109. Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Department of Pharmaceutical Sciences, University of Antwerp (UA), Belgium. vlietink@uta.ua.ac.be
The investigators showed many compounds of plant origin have been identified that inhibit different stages in the replication cycle of human immunodeficiency virus (HIV). Among these compounds, the xanthone mangostin, derived from mangosteen fruit, was shown to inhibit the replication cycle of HIV.
11) Novel types of receptor antagonists from the medicinal plant Garcinia mangostana [Article in Japanese] Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:153P-158P. Furukawa K, Chairungsrilerd N, Ohta T, Nozoe S, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Here the researchers used a crude extract of the fruit hull of Garcinia mangostana L, mangosteen fruit. On the basis of physicochemical data, the active substances were identified as alpha-mangostin and gamma-mangostin in the crude extract. The researchers found that alpha-Mangostin and gamma-mangostin may become novel types of lead compounds for histamine and serotonin receptor antagonists (fight allergies and inflammation).
12) Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. Eur J Pharmacol. 1996 Oct 31;314(3):351-6. Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Researchers found that alpha-mangostin (found in the mangosteen fruit) blocked the binding of histamine to its receptors (fight allergies and inflammation).
13) Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol. 1996 Aug;48(8):861-5. Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R, Miyauchi K. Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
The investigators showed that extracts of Garcinia mangostana, mangosteen fruit, possessed inhibitory effects against the growth of S. aureus (staph bacteria). The strong in-vitro antibacterial activity of xanthone derivatives against both methicillin-resistant and methicillin sensitive Staphylococcus aureus suggests the compounds might find wide pharmaceutical use.
14) Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med. 1996 Aug;62(4):381-2. Chen SX, Wan M, Loh BN.
The investigators found that an extract of Garcinia mangostana L., mangosteen fruit, showed potent inhibitory activity against HIV-1 protease which affects the replication of HIV.
15) Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res. 1995 Aug;23(2):175-84. Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L. University of Western Australia, Department of Medicine, Royal Perth Hospital, Australia.
The oxidation of low density lipoprotein (LDL) may play an important role in atherosclerosis. The researchers investigated the possible antioxidant effects of mangostin, isolated from Garcinia mangostana (found in mangosteen fruit), on the oxidation of human LDL (bad cholesterol). From these results, they concluded that mangostin is acting as a free radical scavenger ("mop up" sponge) to protect the LDL from oxidative damage in this in vitro system. In other words, it a potent antioxdiant.
16) Alpha-mangostin induces Ca(2+)-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol Sci. 2004 May;95(1):33-40. Sato A, Fujiwara H, Oku H, Ishiguro K, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
The researchers investigated the cell death effects of eight xanthones on pheochromocytoma (cancer) cells. Among these compounds, alpha-mangostin, from the fruit hull of Garcinia mangostana L. (mangosteen fruit), had the most potent effect with apoptosis (death) of these cancer cells.
17) Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors. Bioorg Med Chem. 2003 Nov 17;11(23):5171-7. Jiang DJ, Hu GY, Jiang JL, Xiang HL, Deng HW, Li YJ. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
The researchers found that xanthone preserved endothelial cells inhibited the increased adhesion of monocytes to endothelial cells induced by oxidized LDL. This is especially important in preventing plaque formation and the subsequent blockage of arteries and heart disease.
18) Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro. Bioorg Med Chem. 2002 Dec;10(12):3725-30. Pedro M, Cerqueira F, Sousa ME, Nascimento MS, Pinto M. Centro de Estudos de Quimica Organica, Fitoquimica e Farmacologia da Universidade do Porto, Faculdade de Farmacia, Porto, Portugal. madalena@ff.up.pt
Twenty-seven xanthones were assessed for their capacity to inhibit the in vitro the growth of three human cancer cell lines, (breast cancer, renal cancer, melanoma). Inhibition of growth of these cancer cell lines depended on the type of xanthone used in the study.
19) Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod. 2002 May;65(5):761-3. Suksamrarn S, Suwannapoch N, Ratananukul P, Aroonlerk N, Suksamrarn A. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand. sunit@psm.swu.ac.th
Researchers isolated three new xanthones, mangostenol (1), mangostenone A (2), and mangostenone B (3), from the green fruit hulls of Garcinia mangostana, mangosteen fruit. NB: There are about 200 naturally occurring xanthones. The mangosteen fruit (mangostana garcina) possesses 40 of these xanthones with even more being discovered via research.
20) Antihypertensive and vasorelaxing activities of synthetic xanthone derivatives. Bioorg Med Chem. 2002 Mar;10(3):567-72. Wang LW, Kang JJ, Chen IJ, Teng CM, Lin CN. School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, ROC.
The researchers studied a series of xanthones and related compounds. The antihypertensive (against high blood pressure) and vasorelaxing (relaxing of the blood vessels to prevent high blood pressure) activity of compounds on cardiovascular system was evaluated. All the compounds tested exhibited effective hypotensive (lower blood pressure) activity in anesthetized rats.
21) Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 2001 Mar;8(2):85-7. Miura T, Ichiki H, Hashimoto I, Iwamoto N, Kato M, Kubo M, Ishihara E, Komatsu Y, Okada M, Ishida T, Tanigawa K. Suzuka University of Medical Science, Mie, Japan.
Mangiferin, a xanthone, lowered the blood glucose (sugar) level in type II diabetic mice. From these findings, it seems likely that mangiferin exerts its antidiabetic activity by decreasing insulin resistance.
22) Antiplatelets activity of some xanthone derivatives. Acta Pol Pharm. 1999 Jul-Aug;56(4):319-24. Rajtar G, Zolkowska D, Kleinrok Z, Marona H. Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland.
Researchers studied the effects of twelve xanthone derived compounds on platelet aggregation. They found five of them inhibited thrombin-induced platelet aggregation (clot formation).
23) Chiral 2-amino-1-butanol xanthone derivatives as potential antiarrhythmic and hypotensive agents. Acta Pol Pharm. 1999 Jan-Feb;56(1):87-90. Librowski T, Czarnecki R, Jastrzebska M. Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, Krakow, Poland. Cancer Lett. 1998 Oct 23;132(1-2):113-7. Xanthones as inhibitors of Epstein-Barr virus activation. Ito C, Itoigawa M, Furukawa H, Rao KS, Enjo F, Bu P, Takayasu J, Tokuda H, Nishino H. Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Researchers screened 20 xanthones and found that 3 of them to have valuable anti-tumor (against cancer) activities.
24) Synthesis and anticonvulsant effects of some aminoalkanolic derivatives of xanthone. Pharmazie. 1998 Oct;53(10):672-6. Marona H. Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Krakow, Poland.
Researchers studied compounds derived from xanthone for anticonvulsant activities. They found several xanthone derived compounds to be active in anticonvulsant tests.
25) Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336(1):23-8. Cheng YW, Kang JJ. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei.
The researchers showed vasorelaxation (relaxing of blood vessels) activity of the xanthones studied.
26) Xanthones as antimalarial agents; studies of a possible mode of action. FEBS Lett. 1997 Jun 2;409(1):67-73. Ignatushchenko MV, Winter RW, Bachinger HP, Hinrichs DJ, Riscoe MK. Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201, USA.
Researchers showed potent antimalarial activities for the xanthones studied.
27) Synthesis and antithrombotic effect of xanthone derivatives. J Pharm Pharmacol. 1996 Sep;48(9):887-90. Lin CN, Hsieh HK, Liou SJ, Ko HH, Lin HC, Chung MI, Ko FN, Liu HW, Teng CM. School of Pharmacy, Department of Internal Medicine, Kaohsiung Medical College, Taiwan, R.O.C.
Researchers studied several xanthone derived compounds and found them to possess potent antithrombotic (anti clotting) activities.
28) Xanthone derivatives as potential anti-cancer drugs. J Pharm Pharmacol. 1996 May;48(5):539-44. Lin CN, Liou SJ, Lee TH, Chuang YC, Won SJ. School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
Researchers showed xanthone derived compounds to have potent antitumor activities against human cancer cells.
29) Synthesis and anti-inflammatory effects of xanthone derivatives. J Pharm Pharmacol. 1996 May;48(5):532-8. Lin CN, Chung MI, Liou SJ, Lee TH, Wang JP. School of Pharmacy, Kaohsiung Medical College, Taiwan, R.O.C.
The researchers studied 18 xanthone derived compounds and found that some of these compounds possessed strong anti-inflammatory properties.
30) Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases. Biochem Pharmacol. 1994 Jun 15;47(12):2307-10. Thull U, Testa B. Institut de Chimie Therapeutique, Ecole de Pharmacie, Universite de Lausanne, Switzerland.
Of several compounds studied, xanthone emerged as a potent monoamine oxidase inhibitor.
31) Gamma-pyrone compounds as potential anti-cancer drugs. J Pharm Pharmacol. 1993 Sep;45(9):791-4. Liou SS, Shieh WL, Cheng TH, Won SJ, Lin CN. Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.
Researchers studied several compounds and found xanthones with enhanced anti-tumor activity against human cancer cell lines.
"Studies are showing that xanthones have positive effects on nearly all the body's systems, from increased energy to protection from free radical damage, xanthones delivers a wide range of benefits." - Fred Templeman, M.D
Recognized as a category creator, XanGo® Juice is a delicious dietary supplement that harnesses the nutritional attributes of the whole mangosteen fruit through a proprietary formula.
Made from an exclusive puree of the complete mangosteen fruit, XanGo® Juice is a concentrated source of xanthones. Research shows xanthones possess potent antioxidant properties that may help achieve a healthy seasonal respiratory system, boost immune-system health, promote joint ? exibility and maintain intestinal health.*
Through its exclusive whole-fruit mangosteen puree process, XanGo captures the benefits of the entire fruit in its market-leading XanGo® Juice. XanGo’s founders referenced decades of mangosteen studies to support their discovery of a singular dietary mangosteen supplement with a sensational taste. One to three ounces each day is recommended to unleash the power of xanthones in XanGo® Juice.
There has never been a product like XanGo™!
- The Whole Fruit Puree of Prized Mangosteen
- The Best Source Of Powerful Xanthones
- Vital Antioxidants Support
- Indescribably Delicious Flavor
- No Added Sweeteners
- No Artificial Colors
- No Artificial Flavors
A Taste Sensation
And the best part is, XanGo™ is absolutely delicious! We're all familiar with tonics and potions derived from natural plants and herbs. Most have genuine beneficial properties, but the taste leaves so much to be desired. You won't find that with XanGo™. The naturally sweet and tangy flavor of the Mangosteen is a taste sensation you have to experience to believe. XanGo™ has no artificial flavors, no artificial colors, no added sweeteners. We don't need them!
There has never been a product like XanGo™! In one singular drink, you get all of the miraculous benefits of xanthones: powerful antioxidants protection against free radical damage, support for cholesterol concerns, a natural energy enhancer, and more. And you get all this in a drink that you'll look forward to tasting!
Xanthones.
XanGo™ is the only product to use the whole mangosteen fruit in a patented formulation, and contains more xanthones than any other product on earth. Studies are showing that xanthones have positive effects on nearly all of the body's systems. From increased energy to protection from free radical damage, xanthones deliver a wide range of benefits.
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Contributor's Note
Mangosteen has the most xanthones than any other known botanical!
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